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RIMADYL® CAPLETS (carprofen) Tablets Description: Canine non-steroidal anti-inflammatory drug (NSAID) in two oral dosage forms. Selectively inhibits cyclooxygenase (COX)-2, which generates prostaglandins involved in inflammation. (In vitro, clinical relevance has not been shown.) Once-daily dosage provides anti-inflammatory and analgesic effects for 24 hours. Approved Uses RIMADYL® CAPLETS are approved for: Pain and inflammation associated with osteoarthritis in dogs. Control of postoperative pain associated with soft-tissue and orthopedic surgeries in dogs. Key Features First and most widely used veterinary NSAID approved in the U.S. for canine use. Caplets are scored and available in three strengths for convenient dosing. Well tolerated in canine safety studies. Packaging RIMADYL Caplets are scored and contain 25 mg, 75 mg or 100 mg of carprofen per caplet or tablet. Each caplet size is packaged in bottles of 14, 30, 60 or 180 caplets, or in blister packs containing 4 caplets. Dosage and Administration The recommended dosage for oral administration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily. Total daily dose may be administered as 2 mg/lb of body weight once daily or divided and administered as 1 mg/lb (2.2 mg/kg) twice daily. For control of postoperative pain, administer approximately 2 hours before the procedure. Caplets are scored, and dosage should be calculated in half-caplet increments. Precautions See label instructions for complete precautions, warnings and safety information. Federal law restricts this drug to use by or on the order of a licensed veterinarian. RIMADYL should not be used in dogs exhibiting previous hypersensitivity to carprofen. As a class, COX-inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. When NSAIDs inhibit prostaglandins that cause inflammation, they may also inhibit prostaglandins which maintain normal homeostatic function. The most frequently reported effects have been gastrointestinal signs. RIMADYL, like other drugs of its class, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Serious adverse reactions associated with this drug class – including but not limited to gastrointestinal, renal and hepatic signs – can occur without warning and in rare situations result in death. Owners should be advised to discontinue RIMADYL therapy and contact their veterinarian immediately if signs of intolerance are observed. The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively. The safe use of RIMADYL in dogs less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established. Studies to determine the activity of RIMADYL given concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy. Concurrent use of RIMADYL with other anti-inflammatory drugs, such as corticosteroids and NSAIDs, should be avoided or very closely monitored. Keep out of reach of children. Not for human use. For use in dogs only.
Last update : 07-03-2008 06:47
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